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Left bundle branch block as a risk factor for progression to heart failure
Author(s) -
Zannad Faiez,
Huvelle Etienne,
Dickstein Kenneth,
Veldhuisen Dirk J.,
Stellbrink Christoph,
Køber Lars,
Cazeau Serge,
Ritter Philippe,
Maggioni Aldo Pietro,
Ferrari Roberto,
Lechat Philippe
Publication year - 2007
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2006.04.011
Subject(s) - medicine , left bundle branch block , heart failure , cardiology , bundle branch block , cardiac resynchronization therapy , population , electrical conduction system of the heart , risk factor , electrocardiography , ejection fraction , environmental health
The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated. The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra‐ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HF. It also aims to address the potential for future clinical therapies for this conduction disorder.