Premium
Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure
Author(s) -
Biagini Elena,
Valgimigli Marco,
Smits Pieter C.,
Poldermans Don,
Schinkel Arend F.L.,
Rizzello Vittoria,
Onderwater Emile E.M.,
Bountioukos Manolis,
Serruys Patrick W.
Publication year - 2006
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2005.12.004
Subject(s) - medicine , cardiology , ejection fraction , dobutamine , heart failure , doppler imaging , transplantation , heart transplantation , myocardial infarction , dilated cardiomyopathy , cardiomyopathy , hemodynamics , diastole , blood pressure
Background There is experimental evidence that transplanting skeletal myoblasts (SM) into the post‐infarction myocardial scar improves regional and global left ventricular (LV) function. Aims To evaluate short‐ and long‐term regional and global LV functional effects of percutaneously transplanted SM in patients with ischaemic heart failure. Methods and results Ten patients (mean age 60 ± 10 years, 8 males) with dilated ischaemic cardiomyopathy underwent percutaneous injection of autologous myoblasts. Regional and global LV function was evaluated by 2‐dimensional echocardiography and tissue Doppler imaging (TDI) at rest and during low‐dose dobutamine infusion to assess contractile reserve. After a baseline examination, sequential follow‐ups were performed at 1, 3, and 6 months and 1 year. NYHA functional class decreased from 2.7 ± 0.5 to 1.9 ± 0.5 ( p < 0.01) at one year. LV function and volumes at rest remained unchanged while contractile reserve significantly improved during follow‐up. At low‐dose dobutamine infusion, the peak systolic velocity in the regions of myoblasts injection significantly increased at TDI examination (from 7.7 ± 2.1 to 8.6 ± 1.8 cm/s, p = 0.02); LV ejection fraction improved (from 40 ± 9% to 46 ± 8%, p < 0.0001) and end‐systolic volumes decreased (from 56 ± 28 to 50 ± 25 ml/m 2 , p = 0.001) at 1 year. Conclusion In patients with ischaemic heart failure, percutaneous injection of autologous myoblasts may improve regional and global LV systolic function during dobutamine infusion, at 1‐year follow‐up.