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Diagnostic and prognostic value of urine NT‐proBNP levels in heart failure patients
Author(s) -
Cortés Raquel,
Portolés Manuel,
Salvador Antonio,
Bertomeu Vicente,
Burgos Fernando García,
MartínezDolz Luis,
Lletí Esther Roselló,
Climent Vicente,
Jordán Alejandro,
Payá Rafael,
Sogorb Francisco,
Rivera Miguel
Publication year - 2006
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2005.11.011
Subject(s) - medicine , urine , heart failure , urinary system , natriuretic peptide , area under the curve , cardiology , urology , gastroenterology
Background Plasma NT‐proBNP levels are sensitive markers of ventricular dysfunction. However, studies of natriuretic peptides in urine are limited. Aims To compare urine and plasma NT‐proBNP levels and to investigate the diagnostic and prognostic value of urine levels in heart failure (HF). Methods Urinary and plasma NT‐proBNP levels were measured in 96 HF patients and 20 control subjects. The patients were functionally classified according to the NYHA criteria. Results Urine NT‐proBNP was higher in HF patients than in control subjects (94 ± 31 pg/ml vs. 67 ± 6 pg/ml, p < 0.0001), correlating with plasma NT‐proBNP levels ( r = 0.78, p < 0.0001). Urinary levels were elevated in the more severe functional classes and diminished in obese patients. Urine NT‐proBNP was a good tool for diagnosis of HF, the area under the curve (AUC) being 0.96 ± 0.02 ( p < 0.0001), and for predicting 12‐month cardiac events ( p = 0.011). To determine the prognostic power of urinary NT‐proBNP in detecting 12‐month cardiac mortality, we obtained an AUC of 0.75 ± 0.10 ( p = 0.015). Conclusion Urinary NT‐proBNP, a relatively simple non‐invasive test, is a new candidate marker for the diagnosis and evaluation of prognosis in HF and for the characterization of functional status in these patients.