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Role of β1‐ and α2c‐adrenergic receptor polymorphisms and their combination in heart failure: A case‐control study
Author(s) -
Metra Marco,
Zani Claudia,
Covolo Loredana,
Nodari Savina,
Pezzali Natalia,
Gelatti Umberto,
Donato Francesco,
Nardi Giuseppe,
Cas Livio Dei
Publication year - 2006
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2005.07.009
Subject(s) - medicine , odds ratio , heart failure , allele , case control study , endocrinology , genotype , population , adrenergic , receptor , adrenergic receptor , gene , genetics , biology , environmental health
Background: Adrenergic activation has a central role in the development of HF. The function of the β 1 ‐ and the α 2C ‐adrenergic receptors is influenced by gene polymorphisms: the β 1 Arg389 variant is associated with increased β 1 ‐receptor sensitivity and the α 2C ‐receptor Del322–325 variant is associated with decreased α 2C receptor function and increased norepinephrine release. We hypothesised that these polymorphisms could influence the prevalence of heart failure. Methods: The role of the β 1 ‐ and α 2C ‐adrenergic receptor gene polymorphisms as risk factors for heart failure (HF) was assessed in an Italian white Caucasian population using a case‐control study design. Genomic DNA was analysed by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RLFP). Results: We compared 260 Caucasian patients with HF and 230 normal subjects. The β 1 Arg389 allele was frequent both in the patients with HF (69%) and in the normal subjects (73%). The α 2C Del322–325 variant was rare in both groups (9% and 8%, respectively). Patients homozygotes for either the β 1 Arg389 or the α 2C Del322–325 alleles had no increased risk of HF (odds ratio [OR], 0.8; 95%CI: 0.5—1.2 and OR, 0.8; 95% CI: 0.4—1.8, respectively). Patients homozygotes for both the β 1 Arg389 and the α 2C Del322–325 alleles had no increased risk of HF as well (OR: 0.6; 95% CI: 0.2—2.1). Conclusions: β 1 ‐ARs and α 2C ‐ARs polymorphisms are not associated with an increased risk of HF in an Italian white Caucasian population.