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Attenuation of postoperative noradrenaline need by nitric oxide inhibition using L‐NMMA
Author(s) -
FrancoCereceda Anders,
Holm Peter,
Bredin Fredrik,
Adding Christoffer
Publication year - 2005
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2005.02.001
Subject(s) - medicine , nitric oxide , anesthesia , blood pressure , arginine , urinary system , norepinephrine , pharmacology , biochemistry , amino acid , chemistry , dopamine
In the present report we describe that NG‐monomethyl‐L‐arginine acetate, a non‐specific nitric oxide synthesis inhibitor, administered at 1 mg kg –1 h –1 to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pressure while the need for noradrenaline was rapidly attenuated. Again increasing the noradrenaline infusion in the presence of NG‐monomethyl‐L‐arginine acetate caused a dramatic increase of the blood pressure.