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Exercise training in chronic heart failure: effects on pro‐inflammatory markers
Author(s) -
Niebauer Josef,
Clark Andrew L.,
WebbPeploe Katherine M.,
Coats Andrew J.S.
Publication year - 2005
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2004.07.012
Subject(s) - medicine , heart failure , training (meteorology) , cardiology , physical therapy , intensive care medicine , meteorology , physics
Background: Acute bouts of exercise have been shown to induce inflammatory cytokine activation and peripheral hypoxia in patients with chronic heart failure (CHF). In this study, we set out to investigate the impact of chronic exercise training on pro‐inflammatory cytokines and markers of endothelial damage. Methods and results: We measured tumor necrosis factor α (TNFα), its soluble TNF‐receptors 1 and 2, interleukin 6 (IL‐6), soluble e‐selectin, soluble intracellular adhesion molecule‐1 (sICAM) and sCD14 in 18 patients with CHF and 9 age‐matched controls in a randomized cross‐over study of 8 weeks of exercise training (5 days/week, submaximal bicycle ergometer training, 30 min/day; calisthenics 9 min/day) versus 8 weeks of rest. At baseline, patients had a lower peak V o 2 ( p =0.009) and a trend for higher levels of e‐selectin ( p =0.08) and sCD14 ( p =0.06), in addition to significantly elevated levels of sICAM ( p =0.02), TNFα ( p =0.02) and TNF‐R2 ( p =0.002); TNF‐R1 and IL‐6 were not elevated. Although exercise training was effective and led to an increase in peak V o 2 in CHF ( p <0.003), there was no activation of any of the above variables observed, neither in patients nor controls. Conclusions: Chronic heart failure is associated with increased levels of TNFα and markers of endothelial damage. Whereas acute bouts of exercise have been reported to lead to an increase in pro‐inflammatory cytokines and markers of endothelial damage, these effects are not seen when exercise is performed chronically.