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hUNC‐93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men
Author(s) -
Ärnlöv Johan,
Sundström Johan,
Lind Lars,
Andrén Bertil,
Andersson Maria,
Reneland Richard,
Berglund Lars,
Kashuba Vladimir,
Protopopov Alexei,
Zabarovsky Eugene,
Lithell Hans
Publication year - 2005
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2004.06.009
Subject(s) - medicine , heart failure , ejection fraction , cardiology , cohort , diastole , haplotype , population , genotype , gene , genetics , blood pressure , environmental health , biology
Aims: The hUNC‐93B1 gene has the highest expression in the heart. We aimed to explore relationships between the hUNC‐93B1 gene and cardiac function, morbidity and mortality in elderly men. Methods and results: Two sub‐samples of the population‐based ULSAM‐cohort ( n =330, mean age 71 years and n =152, mean age 75 years, respectively) were used to explore and validate relationships between genotypes of the hUNC‐93B1 gene and cardiac phenotypes (ejection fraction, E/A‐ratio, left ventricular mass index and relative wall thickness). In the two samples, subjects homozygous for haplotype H3 had 34% and 35% higher level of E/A‐ratio compared to non‐carriers ( p =0.0002 and 0.017, respectively) independent of cardiovascular disease and medication. Using national cause‐of‐death and hospital‐discharge register data with 29 years of follow‐up, no heart failure patients homozygous for haplotype H3 were hospitalised for heart failure before the age of 75 years, compared to 25% for heterozygous and 55% for non‐carriers ( p <0.03). No homozygous subjects died during follow‐up while 17% of the heterozygous and 15% of the non‐carriers died ( p =0.01). Conclusion: Haplotype H3 of the hUNC‐93B1 gene seems related to E/A‐ratio in elderly men. The relationship between the hUNC‐93B1 gene and the age at onset of heart failure and mortality support a view of a clinically relevant impact of the gene.