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Short‐term prognostic value of initial serum levels of interleukin‐10 in patients with acute myocarditis
Author(s) -
Fuse Koichi,
Kodama Makoto,
Okura Yuji,
Ito Masahiro,
Kato Kiminori,
Hanawa Haruo,
Aizawa Yoshifusa
Publication year - 2005
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2004.03.006
Subject(s) - medicine , myocarditis , acute myocarditis , hazard ratio , pathogenesis , heart failure , gastroenterology , cardiology , interleukin 6 , univariate analysis , multivariate analysis , cytokine , confidence interval
The disease course of acute myocarditis has a wide spectrum and the predictors of the prognosis in patients with acute myocarditis have not yet been established. In the pathogenesis of myocarditis, the cytokine environment is important. In this study, we examined the predictive values of serum levels of interleukin‐10 (IL‐10) and IL‐12 in the short‐term prognosis of patients with acute myocarditis. Twenty‐four consecutive patients who had been diagnosed as having acute active myocarditis were analyzed and monitored for 2 months. The patients with myocarditis were divided into the survival group ( n =16) and the non‐survival group ( n =8). Initial serum levels of IL‐10 ( P =0.0015) and IL‐12 ( P =0.012) in the non‐survival group were significantly higher than those of the survival group, and there was a significant correlation between IL‐10 and IL‐12 levels ( P <0.0001). The univariate analyses showed that increased serum levels of IL‐10 (hazard ratio 1.041, P =0.0004) and IL‐12 (hazard ratio 1.128, P =0.0346) were significant predictors of mortality. In the Kaplan–Meier analysis, high levels of IL‐10 (≥7.0 pg/ml) ( P =0.0239) strongly predicted high mortality. In conclusion, the elevation in serum IL‐10 levels at the initial phase appeared to predict poor short‐term prognosis in patients with acute myocarditis.