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Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO 2 cost of catecholamines in heart failure)
Author(s) -
Nikolaidis Lazaros A.,
Trumble Dennis,
Hentosz Teresa,
Doverspike Aaron,
Huerbin Rhonda,
Mathier Michael A.,
Shen YouTang,
Shan Richard P.
Publication year - 2004
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/j.ejheart.2003.09.013
Subject(s) - medicine , contractility , heart failure , cardiology , dilated cardiomyopathy , blood flow , cardiomyopathy
To investigate the metabolic cost of catecholamine use in heart failure, we administered intravenous dobutamine or norepinephrine to dogs with moderate and severe LV dysfunction until LV contractile function was restored to normal levels. Both drugs were associated with significant increases in myocardial O 2 consumption, increased coronary blood flow requirements and decreased myocardial mechanical efficiency. These mechanisms may contribute to the deleterious effects of catecholamines in heart failure.