Open AccessDevelopment of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material
Author(s) -
Yacine Boumrah,
Martine Rosset,
Yannick Lecompte,
Sabrina Bouanani,
Kamel Khimeche,
Abdallah Dahmani
Publication year - 2014
Publication title -
egyptian journal of forensic sciences/egyptian journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 18
eISSN - 2090-5939
pISSN - 2090-536X
DOI - 10.1016/j.ejfs.2014.03.002
Subject(s) - piperazine , designer drug , methylenedioxy , chromatography , chemistry , mdma , methamphetamine , pseudoephedrine , mescaline , derivatization , gas chromatography–mass spectrometry , ephedrine , amphetamine , mass spectrometry , organic chemistry , drug , pharmacology , hallucinogen , medicine , dopamine , endocrinology , alkyl , halogen
Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives. This paper describes a screening method using a gas chromatography–mass spectrometry technique allowing the separation and the identification of active components within these mixtures by a combined silylation and acylation derivatization procedure. The studied substances–namely: 1-benzylpiperazine (BZP), 1-(3,4-methylenedioxyben-zyl)piperazine (MDBP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP), 1-(4-methoxyphenyl) piperazine (MeOPP), amphetamine, methamphetamine, ephedrine, pseudoephedrine, 3,4-methylenedioxy-N-methamphetamine (MDMA), 3,4-methylenedi-oxyamphetamine (MDA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA) and N-methyl-1,3-benzodioxolylbutanamine (MBDB)–are separated