Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material | Zendy

Yacine Boumrah | Zendy; Martine Rosset | Zendy; Yannick Lecompte | Zendy; Sabrina Bouanani | Zendy; Kamel Khimeche | Zendy; Abdellah Dahmani | Zendy

Open Access

Development of a targeted GC/MS screening method and validation of an HPLC/DAD quantification method for piperazines–amphetamines mixtures in seized material

Author(s) -

Yacine Boumrah,

Martine Rosset,

Yannick Lecompte,

Sabrina Bouanani,

Kamel Khimeche,

Abdellah Dahmani

Publication year - 2014

Publication title -

egyptian journal of forensic sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.238

H-Index - 18

eISSN - 2090-5939

pISSN - 2090-536X

DOI - 10.1016/j.ejfs.2014.03.002

Subject(s) - piperazine , designer drug , methylenedioxy , chromatography , chemistry , mdma , methamphetamine , pseudoephedrine , mescaline , derivatization , gas chromatography–mass spectrometry , ephedrine , amphetamine , mass spectrometry , organic chemistry , drug , pharmacology , hallucinogen , medicine , dopamine , endocrinology , alkyl , halogen

Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives. This paper describes a screening method using a gas chromatography–mass spectrometry technique allowing the separation and the identification of active components within these mixtures by a combined silylation and acylation derivatization procedure. The studied substances–namely: 1-benzylpiperazine (BZP), 1-(3,4-methylenedioxyben-zyl)piperazine (MDBP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP), 1-(4-methoxyphenyl) piperazine (MeOPP), amphetamine, methamphetamine, ephedrine, pseudoephedrine, 3,4-methylenedioxy-N-methamphetamine (MDMA), 3,4-methylenedi-oxyamphetamine (MDA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA) and N-methyl-1,3-benzodioxolylbutanamine (MBDB)–are separated

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