Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism☆ | Zendy

Mitsuo Iwasaki | Zendy; Yukio Hayashi | Zendy; Hiroo Yamanaka | Zendy; Takahiko Kamibayashi | Zendy; Takashi Mashimo | Zendy

Open Access

Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism☆

Author(s) -

Mitsuo Iwasaki,

Yukio Hayashi,

Hiroo Yamanaka,

Takahiko Kamibayashi,

Takashi Mashimo

Publication year - 2011

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2010.12.045

Subject(s) - nicorandil , ejection fraction , potassium channel opener , potassium channel , medicine , ventricle , cardiology , anesthesia , adenosine triphosphate , adenosine , pharmacology , heart failure

Interventions to preserve myocardial function after brain death may increase the donor pool for heart transplantation. The present study using a brain death model of rats was designed to examine the protective potential of nicorandil, an adenosine triphosphate-sensitive potassium channel opener, on myocardial function after brain death.

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