Open AccessSearching for the least invasive parameters used as predictors of survival in idiopathic pulmonary arterial hypertension
Author(s) -
B.A. Naglaa,
Reem I. El-Korashy,
Youssef Soliman
Publication year - 2015
Publication title -
egyptian journal of chest diseases and tuberculosis/egyptian journal of chest diseases and tuberculosis
Language(s) - English
Resource type - Journals
eISSN - 2090-9950
pISSN - 0422-7638
DOI - 10.1016/j.ejcdt.2015.04.005
Subject(s) - medicine , depression (economics) , statistical significance , survival rate , pulmonary hypertension , economics , macroeconomics
IPAH is a debilitating disease that is not curable and needs regular long term monitoring, where the gold standard for diagnosing and monitoring patients, is right heart catheter.AimSearching for the least invasive parameters possible to use as predictors of survival in IPAH patientsMethodologyThe study included 14 IPAH patients, for all PASP, SpO2, 6MWD, FC, PHQ9 depression score and targeted treatment pattern were assessed and the overall survival in 12, 24, 36, and 48months in relation to the mentioned parameters was calculated.ResultsThe overall survival was 64.29% in 12months following diagnosis, 56.25% in 24months, 46.88% in 36months and 35.16% in 48months. The overall survival was only statistically significant in the groups of depression measured by PHQ-9. Most patients presented in functional class II and III. Though SpO2, 6MWD and mono Versus combined therapy did not show statistical significance in the overall survival, yet there was obvious higher overall survival in patients with SpO2⩾90%, 6MWD>300m and in first year of treatment with combined therapy.ConclusionThe most significant parameter affecting survival was depression score using PHQ-9. It was also observed that the highest mortality was in the first year of diagnosis although it was not statistically significant. Thus, a wider scale study is needed for the idiopathic pulmonary hypertension patients to better assess their survival pattern