Open AccessMatrix metalloproteinase-9 (MMP9) and high sensitivity C – reactive protein (hs-CRP) in coronary artery ectasia
Author(s) -
Waleed Ammar,
Mahmoud Kappary,
Yasser Baghdady,
Mohamed Shehata
Publication year - 2014
Publication title -
the egyptian heart journal /the egyptian heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 2090-911X
pISSN - 1110-2608
DOI - 10.1016/j.ehj.2013.12.042
Subject(s) - coronary artery ectasia , medicine , ectasia , matrix metalloproteinase , coronary artery disease , c reactive protein , mmp9 , extracellular matrix , cardiology , gastroenterology , artery , matrix metalloproteinase 3 , inflammation , coronary angiography , myocardial infarction , chemistry , biochemistry , downregulation and upregulation , gene
ObjectiveThe specific causative mechanisms of abnormal luminar dilatation in coronary artery ectasia (CAE) are essentially unknown. Destruction of extracellular matrix may be responsible for the ectasia formation. Thus, we investigated the role of matrix metalloproteinases (MMP9), and inflammatory marker (high-sensitive C-reactive protein) in CAE patients.MethodsThis study consisted of 30 consecutive CAE patients, 30 obstructive coronary artery disease (CAD) patients, and 20 controls with normal coronary arteries undergoing cardiac catheterization. Plasma levels of MMP-9, and hs-CRP were measured.ResultsHs-CRP level was significantly higher in the CAE group than both in CAD and control groups (2.3±0.5, 1.19±0.54, 0.8±0.3mg/l, respectively , both p<0.001), while , MMP-9 level was significantly higher in both CAE group and CAD than control groups (27.71±4.7, 25.2±4.1 , 18.6±3.3ng/ml, respectively , both p<0.001). In subgroup analyses, MMP-9 level was significantly higher in CAE patients with multivessel involvement compared with those with single-vessel ectasia (29.4±3.1 vs. 25.2±5.5ng/ml, P=0.01), while hs CRP level was comparable in both groups (2.3±0.52 vs. 2.4±0.45ng/ml, P=0.82).ConclusionOur results suggest that the increased levels of MMP-9, hs-CRP may be responsible for ectasia formation in patients with CAE and plasma level of MMP-9 is correlated with the severity of CAE