Open AccessBaseline QRS width and mitral regurgitation behavior after cardiac resynchronization therapy among patients with dilated cardiomyopathy
Author(s) -
Salah Atta,
Mohamed Bashandy,
Sherif Zaky
Publication year - 2014
Publication title -
the egyptian heart journal /the egyptian heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 2090-911X
pISSN - 1110-2608
DOI - 10.1016/j.ehj.2013.08.005
Subject(s) - medicine , cardiac resynchronization therapy , cardiology , dilated cardiomyopathy , qrs complex , mitral regurgitation , left bundle branch block , heart failure , ejection fraction , cardiomyopathy
BackgroundThe effect of cardiac resynchronization therapy (CRT) on functional mitral regurgitation (FMR) is reflected on both clinical and echocardiographic response. We sought to assess the behavior of FMR and the response to CRT implantation in relation to the baseline width of the QRS complex among patients with dilated cardiomyopathy (DCM).Patients and methodsThis is a prospective observational case-control study, including forty patients with advanced DCM who had left bundle branch block (LBBB), QRS⩾130ms (group 1) and 10 patients with QRS<130ms (group 2) both with echocardiographic evidence of dyssynchrony and subjected to CRT in our center.ResultsEvidence of response to CRT at 6months, was observed in 31 patients (77.5%) of group 1 Vs 2 (20%) patients of group 2 (p. 0.001). MR improvement was higher among responders to CRT in 31/33 (93.9%) Vs 2/17 patients (11.7%) of the non responders (p. 0.003). FMR improvement was observed in 31 patients of group 1 (77.5%) Vs 2 patients of group 2 (20%) p. value 0.001.ConclusionAmong patients with DCM, the degree of FMR regression after CRT seems to be more clear in patients with a baseline QRS width ⩾130ms and this seems to be associated with better response of the patients to CRT