Case – Control study of potential culprit procedures for infective endocarditis in an Egyptian tertiary care center

BackgroundInfective endocarditis (IE) is associated with substantial morbidity and mortality. However, there are conflicting views as to the significance of bacteremia caused by interventional procedures in the existing clinical guidelines.ObjectivesFormal evaluation of risk factors for IE is lacking in Egyptian tertiary care centers. We test the hypothesis that underlying medical conditions, not culprit procedures, are the most important risk factor for development of IE.MethodsWe matched 175 patients with definite IE from IE database of the Cardiology Department, Cairo University Hospital with175 control cases without IE, matched for age, sex, and underlying heart disease. Demographic and clinical data, comorbidities and potential culprit procedures during the 3months prior to the diagnosis of IE were recorded.ResultsHost-related risk factors included renal impairment (p<0.001), renal dialysis (p=0.003) and prior episode of IE (p=0.03). Procedure-related risk factors included a history of hospitalization for at least 24h in the preceding 3months (p<0.001), and use of peripheral intravenous line (p=0.005). Dental procedures were not risk factors for IE. Staphylococcus aureus was the most prevalent procedure-related microorganism (27.3 %), followed by Streptococcus species in 15.9% of cases.ConclusionsHospitalization for at least 24h within the preceding 3months, peripheral IV line placement, renal impairment and prior IE were significant risk factors for IE. Staphylococci were the predominant microorganisms. These results suggest a nosocomial source of infection and call for reinforcement of infection prevention interventions in Egyptian hospitals especially in high-risk patients