Relation between serum B-type brain natriuretic peptide level and complexity & severity of coronary artery disease in non-ST elevation myocardial infarction

BackgroundNeurohumoral activation of the heart can be monitored by measurements of systemic levels of natriuretic peptides, such as BNP. Patients with non ST-elevation myocardial infarction (NSTEMI) with elevated BNP levels had an increased mortality rate when compared with those with lower levels. The SYNTAX score is a novel anatomical tool characterizing coronary vasculature and grades the complexity of coronary artery disease.Patients and methodsThe study included 58 patients with NSTEMI “Group I” (72.5%) and 22 patients as a control “Group II” (27.5%) with typical chest pain, and coronary angiography revealed healthy coronaries. Analysis of blood samples for troponin-I, CKMB, and BNP levels was performed within 24h of hospital admission, all patients underwent echocardiographic examination to exclude systolic dysfunction. Both groups were referred to coronary angiography.ResultsThis study included 58 patients with NSTEMI “Group I” (72.5%) and 22 patients as a control “Group II” (27.5%), the serum level of BNP was significantly higher in patients with the NSTEMI “group I” (37.7±32.06) than the control “group II” (1.82±5.9) p value (0.0001). The levels of BNP were positively correlated with the LAD involvement in coronary angiography. There was a positive correlation between the serum level of BNP and number of coronary vessels involved (r=0.75) and Degree of SYNTAX score (r=0.78).ConclusionThere was a significant relationship between the serum level of BNP and number of coronary arteries involved and complexity of the lesions in NSTEMI as regards SYNTAX score