Open AccessSerum resistin in acute myocardial infarction patients with and without diabetes mellitus
Author(s) -
Hussein Ibrahim,
Tarek E. Korah,
Eman Badr,
Maathir Kamel El-Shafie
Publication year - 2012
Publication title -
the egyptian heart journal /the egyptian heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.212
H-Index - 9
eISSN - 2090-911X
pISSN - 1110-2608
DOI - 10.1016/j.ehj.2011.08.036
Subject(s) - resistin , medicine , insulin resistance , endocrinology , myocardial infarction , diabetes mellitus , adipokine , high density lipoprotein , body mass index , insulin , cholesterol
AimHuman resistin is an adipokine, which has been suggested to be an inflammatory marker, with possible links to atherosclerosis and coronary heart disease. Meanwhile, the relationship between serum resistin, insulin resistance, and type 2 diabetes mellitus (T2DM) is still controversial. Therefore, this study aimed to assess serum resistin in patients with acute ST-segment elevation myocardial infarction (STEMI), with and without T2DM.Patients and methodsA total of 55 subjects included in this study, were categorized into three groups: 20 non-diabetic patients with acute STEMI (group I), 20 diabetic patients with acute STEMI (group II), and 15 healthy age and gender-matched controls (group III). Levels of serum lipids, fasting blood glucose (FBG), insulin, troponin I, creatine kinase (CK), lactate dehydrogenase (LDH), and resistin, were estimated.ResultsSerum total cholesterol, low density lipoprotein cholesterol (LDLc), FBG, troponin I, CK (total and MB), LDH, and resistin, were significantly higher in group II, than in group I and group III (p<0.05). In group II, serum resistin was positively correlated with serum troponin I and TG (r=0.59, p<0.05 and r=0.47, p<0.05, respectively), but was negatively correlated with high density lipoprotein cholesterol (HDLc) (r=−0.46, p>0.05). However, in this patients’ group, serum resistin was not correlated with age, gender, body mass index (BMI), total cholesterol, FBG, insulin, CK, LDH, and the calculated homeostasis model for insulin resistance (HOMA-IR) (p>0.05). As regards group I, serum resistin was not correlated to any of these studied parameters (p>0.05).ConclusionSerum resistin levels are elevated in patients with acute STEMI. This increase is more evident in patients with T2DM than those without T2DM, denoting higher degrees of inflammation. However, serum resistin is not correlated with age, gender, BMI, and insulin resistance. These data denote that serum resistin concentration might be used as a diagnostic biomarker for acute STEMI. In addition, optimization of the treatment of T2DM could improve cardioprotection