Open AccessCD68-negative nonlipidized juvenile xanthogranuloma
Author(s) -
TzuKun Lo,
Kung-Chao Chang,
Chia-Bao Chu,
Julia Yu-Yun Lee
Publication year - 2017
Publication title -
dermatologica sinica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.604
H-Index - 17
eISSN - 2223-330X
pISSN - 1027-8117
DOI - 10.1016/j.dsi.2017.01.005
Subject(s) - juvenile xanthogranuloma , histiocyte , medicine , cd68 , factor xiiia , pathology , histiocytosis , cd163 , giant cell , macrophage , immunohistochemistry , biology , biochemistry , disease , in vitro
Juvenile xanthogranuloma (JXG) belongs to the group of non-Langerhans cell histiocytosis. JXG is typically factor XIIIa- and CD68-positive. Nonlipidized JXG (NJXG) is a rare, mononuclear variant of JXG that shows few or absence of foam cells or Touton giant cells in the histiocytic infiltrate. Herein, we describe an unusual case of NJXG in a 7-year-old boy presenting with a 1-month history of a flesh-colored nodule on the forehead. The lesion was factor XIIIa-positive and CD68-negative but CD163-positive. Our case illustrates that CD163, a more specific marker of macrophage and monocyte differentiation, is a valuable marker for the diagnosis of NJXG
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