Two cases of bullous systemic lupus erythematosus treated successfully with T2 and low-dose corticosteroids | Zendy

Guangping Wang | Zendy; Caimei Wang | Zendy; Xiulian Xu | Zendy; Hong Jia | Zendy

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Two cases of bullous systemic lupus erythematosus treated successfully with T2 and low-dose corticosteroids

Author(s) -

Guangping Wang,

Caimei Wang,

Xiulian Xu,

Hong Jia

Publication year - 2015

Publication title -

dermatologica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.604

H-Index - 17

eISSN - 2223-330X

pISSN - 1027-8117

DOI - 10.1016/j.dsi.2015.08.004

Subject(s) - medicine , prednisone , anti nuclear antibody , dermatology , tripterygium wilfordii , lupus erythematosus , gastroenterology , synovitis , immunology , antibody , rheumatoid arthritis , pathology , autoantibody , alternative medicine

Two female patients presented with bullous cutaneous lupus on sun-exposed areas and synovitis, and tested positive for antinuclear antibodies, anti-Smith (anti-Sm), anti-dsDNA, and low complement levels. Case 2 also suffered oral ulcers. Thus, diagnoses of bullous systemic lupus erythematosus (BSLE) were made. Both patients responded distinctly to Tripterygium wilfordii polyglycosidium (T2; 60 mg/day) combined with oral prednisone (30–40 mg/day), which showed efficacy in 1–2 weeks and produced no side effects. Therefore, T2 combined with low-dose corticosteroids may be an effective and highly tolerable alternative for treating BSLE

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