Early childhood stress is associated with blunted development of ventral tegmental area functional connectivity
Author(s) -
Anne T. Park,
Ursula A. Tooley,
Julia A. Leonard,
Austin L. Boroshok,
Cassidy L. McDermott,
M. Dylan Tisdall,
Allyson P. Mackey
Publication year - 2020
Publication title -
developmental cognitive neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.662
H-Index - 64
eISSN - 1878-9307
pISSN - 1878-9293
DOI - 10.1016/j.dcn.2020.100909
Subject(s) - ventral tegmental area , psychology , nucleus accumbens , neuroscience , prefrontal cortex , dopaminergic , dopamine , hippocampus , brain stimulation reward , developmental psychology , cognition
Highlights • Age-related changes in VTA-mPFC connectivity are moderated by SES and early adversity.• Connectivity between the VTA and caudate increases with age in childhood.• Findings are consistent with rodent models showing stress susceptibility in the VTA.• Stress exposure may blunt the development of reward circuitry in childhood.
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