Open AccessUtility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia
Author(s) -
Hackett Katherine,
Krikorian Robert,
Giovannetti Tania,
MelendezCabrero Josefina,
Rahman Aneela,
Caesar Emily E.,
Chen Jaclyn L.,
Hristov Hollie,
Seifan Alon,
Mosconi Lisa,
Isaacson Richard S.
Publication year - 2018
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2018.10.002
Subject(s) - dementia , cognition , neurocognitive , neuropsychology , psychology , disease , clinical psychology , medicine , psychiatry
The NIH Toolbox Cognition Battery (NIHTB‐CB) is a computer‐based protocol not yet validated for clinical assessment. Methods We administered the NIHTB‐CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity. Discriminant function analyses compared classification accuracy. Results Principal component analysis identified three conceptually coherent factors: memory (MEM NIH ), executive function (EF NIH ), and crystallized intelligence (CI NIH ). These factors were strongly associated with corresponding traditional tests and differed across diagnostic groups as expected. Both NIHTB and traditional batteries yielded strong overall discriminative ability (>80%). Discussion The NIHTB‐CB is a valid method to assess neurocognitive domains pertinent to aging and dementia and has utility for applications in a memory clinic setting.