Open AccessAltered functional connectivity strength in informant‐reported subjective cognitive decline: A resting‐state functional magnetic resonance imaging study
Author(s) -
Dong Chao,
Liu Tao,
Wen Wei,
Kochan Nicole A.,
Jiang Jiyang,
Li Qiongge,
Liu Hao,
Niu Haijun,
Zhang Wei,
Wang Yilong,
Brodaty Henry,
Sachdev Perminder S.
Publication year - 2018
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2018.08.011
Subject(s) - precuneus , posterior cingulate , functional magnetic resonance imaging , cuneus , psychology , resting state fmri , neuroimaging , neuroscience , dementia , cognition , magnetic resonance imaging , brain mapping , audiology , medicine , disease , radiology
Informant‐reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited. Methods The sample comprised 39 participants with iSCD and 39 age‐ and sex‐ matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z‐scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness. Results The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed. Discussion There are detectable changes of FCS in iSCD, with the precuneus possibly playing a compensatory role. FCS could therefore have a potential role to serve as one of the earliest neuroimaging markers of neurodegenerative disease.