Open AccessEvaluating combinations of diagnostic tests to discriminate different dementia types
Author(s) -
Bruun Marie,
RhodiusMeester Hanneke F.M.,
Koikkalainen Juha,
Baroni Marta,
Gjerum Le,
Lemstra Afina W.,
Barkhof Frederik,
Remes Anne M.,
Urhemaa Timo,
Tolonen Antti,
Rueckert Daniel,
Gils Mark,
Frederiksen Kristian S.,
Waldemar Gunhild,
Scheltens Philip,
Mecocci Patrizia,
Soininen Hilkka,
Lötjönen Jyrki,
Hasselbalch Steen G.,
Flier Wiesje M.
Publication year - 2018
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2018.07.003
Subject(s) - dementia , dementia with lewy bodies , frontotemporal dementia , vascular dementia , magnetic resonance imaging , differential diagnosis , pathology , diagnostic accuracy , medicine , cognitive test , disease , psychology , cognition , audiology , radiology , neuroscience
We studied, using a data‐driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia. Methods In this multicenter study, we included 356 patients with Alzheimer's disease, 87 frontotemporal dementia, 61 dementia with Lewy bodies, 38 vascular dementia, and 302 controls. We used a classifier to assess accuracy for individual performance and combinations of cognitive tests, cerebrospinal fluid biomarkers, and automated magnetic resonance imaging features for pairwise differentiation between dementia types. Results Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%. Discussion Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.