Open AccessEntorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry
Author(s) -
Tward Daniel J.,
Sicat Chelsea S.,
Brown Timothy,
Bakker Arnold,
Gallagher Michela,
Albert Marilyn,
Miller Michael
Publication year - 2017
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2017.07.005
Subject(s) - entorhinal cortex , atrophy , cognitive impairment , neuroimaging , autopsy , neuroscience , cognition , alzheimer's disease , cortex (anatomy) , dementia , medicine , temporal cortex , psychology , disease , pathology , audiology , hippocampus
Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease. Methods Here, we study this region in subjects with mild cognitive impairment ( n = 36) and in control subjects ( n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time. Results We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing. Discussion This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.