Open AccessChanges in metabolic risk factors over 10 years and their associations with late‐life cognitive performance: The Multi‐Ethnic Study of Atherosclerosis
Author(s) -
Hughes Timothy M.,
Craft Suzanne,
Baker Laura D.,
Espeland Mark A.,
Rapp Stephen R.,
Sink Kaycee M.,
Bertoni Alain G.,
Burke Gregory L.,
Gottesman Rebecca F.,
Michos Erin D.,
Luchsinger José A.,
Fitzpatrick Annette L.,
Hayden Kathleen M.
Publication year - 2017
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2017.03.003
Subject(s) - effects of sleep deprivation on cognitive performance , blood pressure , cognition , medicine , memory span , cognitive decline , atherosclerosis risk in communities , ethnic group , cognitive test , audiology , gerontology , cardiology , dementia , psychiatry , disease , working memory , sociology , anthropology
Background We examined whether changes in metabolic factors over 10 years were associated with cognitive performance. Methods Participants from the Multi‐Ethnic Study of Atherosclerosis were followed since baseline (2000–2002) with five clinical examinations. At exam 5 (2010–2012), they received a short cognitive battery (Cognitive Abilities Screening Instrument [CASI], Digit Symbol Coding [DSC], and Digit Span [DS]). We examined associations between baseline metabolic factors and their changes over time before cognitive testing. Results Among 4392 participants, baseline metabolic disorders (fasting glucose, systolic and diastolic blood pressures) were significantly associated with poorer CASI, DSC, and DS scores measured 10 years later. Increases in blood pressure were associated with lower cognitive performance. Results did not differ by race/ethnicity and were stronger among those without the APOE ε4 allele. Conclusions Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases. Findings appeared stronger among APOE ε4‐negative participants.