Open AccessApolipoproteins and their subspecies in human cerebrospinal fluid and plasma
Author(s) -
Koch Manja,
Furtado Jeremy D.,
Falk Kim,
Leypoldt Frank,
Mukamal Kenneth J.,
Jensen Majken K.
Publication year - 2017
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2017.01.007
Subject(s) - subspecies , cerebrospinal fluid , apolipoprotein e , apolipoprotein b , medicine , endocrinology , pathophysiology , chemistry , cholesterol , biology , disease , paleontology
Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins. Methods We determined age‐ and sex‐adjusted correlations of enzyme‐linked immunosorbent assay–measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA‐I, apoC‐III, apoE, and apoJ) or apolipoprotein subspecies (apoA‐I with and without apoC‐III, ApoE, or apoJ; apoE with and without apoC‐III or apoJ) in 22 dementia‐free participants. Results CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA‐I without apoJ ( r = 0.7). CSF apoA‐I correlated similarly strong with plasma total apoA‐I and all apoA‐I subspecies ( r ≥ 0.4) except for apoA‐I with apoE ( r = 0.3) or apoA‐I with apoJ ( r = 0.3). CSF apoC‐III was most strongly correlated with plasma apoA‐I with apoC‐III ( r = 0.7). Discussion CSF levels of some apolipoproteins implicated in the pathophysiology of dementia might be better approximated by specific plasma apolipoprotein subspecies than total plasma concentrations.