Open AccessAlzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design
Author(s) -
Wilde Arno,
Maurik Ingrid S.,
Kunneman Marleen,
Bouwman Femke,
Zwan Marissa,
Willemse Eline A.J.,
Biessels Geert Jan,
Minkman Mirella,
Pel Ruth,
Schoonenboom Niki S.M.,
Smets Ellen M.A.,
Wattjes Mike P.,
Barkhof Frederik,
Stephens Andrew,
Lier Erik J.,
BatrlaUtermann Richard,
Scheltens Philip,
Teunissen Charlotte E.,
Berckel Bart N.M.,
Flier Wiesje M.
Publication year - 2017
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2017.01.003
Subject(s) - positron emission tomography , medical physics , magnetic resonance imaging , medicine , neuroimaging , set (abstract data type) , cognitive impairment , memory clinic , clinical practice , interpretation (philosophy) , cognition , computer science , psychology , physical therapy , radiology , psychiatry , programming language
The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI) Methods ABIDE is a 3‐year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods. Results Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice. Furthermore, ABIDE will develop strategies for optimal patient‐clinician conversations. Discussion Ultimately, this will result in a set of practical tools for clinicians to support the choice of diagnostic tests and facilitate the interpretation and communication of their results.