English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear.    Methods  Inflammatory markers were assayed in 54 elderly participants ( n  = 16 with AD). Periventricular WMH were delineated from T1, T2/proton density, and fluid‐attenuated magnetic resonance imaging using semiautomated fuzzy lesion extraction and coregistered with maps of fractional anisotropy (FA), a measure of microstructural integrity assessed using diffusion tensor imaging.    Results  Mean FA within periventricular WMH was associated with an inflammatory factor consisting of interleukin (IL)‐1β, tumor necrosis factor, IL‐10, IL‐21, and IL‐23 in patients with AD (ρ = −0.703,  P  = .002) but not in healthy elderly (ρ = 0.217,  P  = .190). Inflammation was associated with greater FA in deep WMH in healthy elderly (ρ = 0.425,  P  = .008) but not in patients with AD (ρ = 0.174,  P  = .520).    Discussion  Peripheral inflammatory markers may be differentially related to microstructural characteristics within the white matter affected by cerebral small vessel disease in elders with and without AD.

alzheimer's and dementia: diagnosis, assessment and disease monitoring

Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report