English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether  APOE  ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD).    Methods  Brain magnetic resonance imaging (MRI) scans were acquired in 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 mild AD dementia) and CSF concentrations of YKL‐40 and sTREM2 were determined. Differences in CSF biomarker concentrations and interactions in their association with gray‐matter volume according to  APOE  ε4 status were sought after.    Results  Preclinical and MCI carriers showed higher YKL‐40 levels. There was a significant interaction in the association between YKL‐40 levels and gray‐matter volume according to ε4 status. No similar effects could be detected for sTREM2 levels.    Discussion  Our findings are indicative of an increased astroglial activation in  APOE  ε4 carriers while both groups displayed similar levels of CSF AD core biomarkers.

alzheimer's and dementia: diagnosis, assessment and disease monitoring

The  APOE  ε4 genotype modulates CSF YKL‐40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2