Open AccessAssessing quality of life in Alzheimer's disease: Implications for clinical trials
Author(s) -
KahleWrobleski Kristin,
Ye Wenyu,
Henley David,
Hake Ann Marie,
Siemers Eric,
Chen YunFei,
LiuSeifert Hong
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.11.004
Subject(s) - quality of life (healthcare) , clinical trial , context (archaeology) , medicine , dementia , disease , alzheimer's disease , physical therapy , biology , paleontology , nursing
Characterization of the quality of life (QOL) in Alzheimer's disease (AD) scale within the context of a clinical trial may inform its applicability in future trials. Methods Using data from 1322 patients enrolled in two phase‐III studies (EXPEDITION 1 [ NCT00905372 ] and 2 [ NCT00904683 ]) of intravenous solanezumab in outpatients with mild AD dementia, correlations between patient‐ and caregiver‐assessed QOL and between QOL and clinical outcome measures were examined. Longitudinal effects of solanezumab over 80 weeks were explored, controlling for patient and caregiver baseline characteristics. Results Caregivers rated patients' QOL worse than did patients themselves. Patients' QOL was correlated, albeit modestly, with clinical/health measures. Patients' QOL changed minimally over 80 weeks, although a treatment effect of solanezumab on QOL was detected. Discussion Further investigations are needed to determine the optimal measures with which to quantify and qualify QOL of patients with mild AD.