Open AccessMiddle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years
Author(s) -
Vuoksimaa Eero,
Rinne Juha O.,
Lindgren Noora,
Heikkilä Kauko,
Koskenvuo Markku,
Kaprio Jaakko
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.08.003
Subject(s) - dementia , confidence interval , cognition , population , framingham risk score , demography , gerontology , psychology , medicine , clinical psychology , psychiatry , disease , sociology
On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments. Results The prevalence of dementia was 10% after a mean follow‐up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow‐up of 39 years in the replication sample. Discussion Self‐report risk score predicted cognitive functioning and dementia risk 20–40 years later.