Open AccessPlasma exosome concentration may correlate with cognitive impairment in Parkinson's disease
Author(s) -
Alamri Yassar,
Vogel Robert,
MacAskill Michael,
Anderson Tim
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.08.002
Subject(s) - nanoparticle tracking analysis , microvesicles , exosome , montreal cognitive assessment , cognition , parkinson's disease , medicine , dementia , cognitive impairment , disease , chemistry , psychiatry , microrna , biochemistry , gene
We read the recent findings by Winston et al. [1] with great interest. The quantification of extracellular vesicles (including exosomes) has presented several challenges despite the availability of a number biophysical techniques, including nanoparticle tracking analysis (NanoSight, Ltd.) and tunable resistive pulse sensing (Izon Science, Ltd.) [2]. These challenges are mainly due to the small size and polydispersity of exosomes and the lack of a standardized methodology for measuring exosomes which allows results from different days, users, and instruments to be compared [3].