Open AccessUpdate on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
Author(s) -
Andreasson Ulf,
Blennow Kaj,
Zetterberg Henrik
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.05.005
Subject(s) - cerebrospinal fluid , biomarker , central nervous system , medicine , biomarker discovery , neuroscience , bioinformatics , computational biology , pathology , biology , proteomics , biochemistry , gene
Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS‐specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders.