Open AccessMCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes
Author(s) -
Bettcher Brianne M.,
Fitch Ryan,
Wynn Matthew J.,
Lalli Matthew A.,
Elofson Jonathan,
Jastrzab Laura,
Mitic Laura,
Miller Zachary A.,
Rabinovici Gil D.,
Miller Bruce L.,
Kao Aimee W.,
Kosik Kenneth S.,
Kramer Joel H.
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.05.004
Subject(s) - dementia , psychology , eotaxin , alzheimer's disease , context (archaeology) , neuroscience , phenotype , temporal lobe , medicine , disease , pathology , chemokine , biology , genetics , inflammation , epilepsy , gene , paleontology
MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. Methods MCP‐1 and eotaxin‐1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained. Results An interaction was noted between MCP‐1 and eotaxin‐1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non‐chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains. Discussion These results suggest a potentially selective role for MCP‐1 and eotaxin‐1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.