Open AccessEffects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects
Author(s) -
Glodzik Lidia,
Rusinek Henry,
Kamer Angela,
Pirraglia Elizabeth,
Tsui Wai,
Mosconi Lisa,
Li Yi,
McHugh Pauline,
Murray John,
Williams Schantel,
Osorio Ricardo S.,
Randall Catherine,
Butler Tracy,
Deshpande Anup,
Vallabhajolusa Shankar,
Leon Mony
Publication year - 2016
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2016.02.007
Subject(s) - overweight , medicine , endocrinology , dementia , obesity , blood pressure , atorvastatin , amyloid (mycology) , disease , pathology
Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition. Methods A cross‐sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta‐blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition. Results The use of ARBs (β = −.15, P = .044) and diuretics (β = −.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. Discussion Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.