Open AccessA clinical trial to validate event‐related potential markers of Alzheimer's disease in outpatient settings
Author(s) -
Cecchi Marco,
Moore Dennis K.,
Sadowsky Carl H.,
Solomon Paul R.,
Doraiswamy P. Murali,
Smith Charles D.,
Jicha Gregory A.,
Budson Andrew E.,
Arnold Steven E.,
Fadem Kalford C.
Publication year - 2015
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2015.08.004
Subject(s) - event related potential , cognition , latency (audio) , audiology , oddball paradigm , disease , working memory , psychology , medicine , neuroscience , computer science , telecommunications
We investigated whether event‐related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD). Methods A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm. Results Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test. Discussion Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.