The emerging role of cellular senescence in complications of COVID-19 | Zendy

Md Mohiuddin | Zendy; Kazuo Kasahara | Zendy

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The emerging role of cellular senescence in complications of COVID-19

Author(s) -

Md Mohiuddin,

Kazuo Kasahara

Publication year - 2021

Publication title -

cancer treatment and research communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.459

H-Index - 10

ISSN - 2468-2942

DOI - 10.1016/j.ctarc.2021.100399

Subject(s) - covid-19 , pandemic , senescence , cellular senescence , disease , medicine , cancer , intensive care medicine , biology , virology , pathology , infectious disease (medical specialty) , genetics , gene , outbreak , phenotype

The coronavirus disease 2019 (COVID-19) pandemic has triggered a sudden global change in healthcare systems. Cancer patients have a higher risk of death from COVID-19 in comparison to patients without cancer. Many studies have stated that various factors, such as older age, frequent exposure to healthcare, and higher smoking rates are responsible for the complications of COVID-19. We hypothesize that side effects of chemotherapy, such as cellular senescence, could worsen COVID-19. Given this situation, in this review, we highlight the updated findings of research investigating the impact of cellular senescence on COVID-19 complications and explored potential therapeutic targets for eliminating senescent cells during the COVID-19 pandemic.

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