Genetic modification of the human germ line: The reasons why this project has no future
Author(s) -
Michel Morange
Publication year - 2015
Publication title -
comptes rendus biologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.529
H-Index - 84
eISSN - 1768-3238
pISSN - 1631-0691
DOI - 10.1016/j.crvi.2015.07.005
Subject(s) - eugenics , germline , germ , line (geometry) , environmental ethics , biology , political science , genetics , philosophy , mathematics , geometry , gene , microbiology and biotechnology
Modification of the human germ line has remained a distant but valuable objective for most biologists since the emergence of genetics (and even before). To study the historical transformations of this project, I have selected three periods - the 1930s, at the pinnacle of eugenics, around 1974 when molecular biology triumphed, and today - and have adopted three criteria to estimate the feasibility of this project: the state of scientific knowledge, the existence of suitable tools, and societal demands. Although the long-awaited techniques to modify the germ line are now available, I will show that most of the expectations behind this project have disappeared, or are considered as being reachable by highly different strategies.
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