Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity | Zendy

Kévin Fourmy | Zendy; Maryse Gouygou | Zendy; Odile DechyCabaret | Zendy; Françoise Benoît-Vical | Zendy

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Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

Author(s) -

Kévin Fourmy,

Maryse Gouygou,

Odile DechyCabaret,

Françoise Benoît-Vical

Publication year - 2016

Publication title -

comptes rendus chimie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.653

H-Index - 76

eISSN - 1878-1543

pISSN - 1631-0748

DOI - 10.1016/j.crci.2016.06.008

Subject(s) - ligand (biochemistry) , phosphole , chemistry , stereochemistry , moiety , medicinal chemistry , receptor , biochemistry

A series of gold(I)-monophosphole complexes have been synthesized and characterized. The introduction of a nitrogen moiety in the complex structure was envisioned either by choosing the bis(trifluoromethanesulfonyl)imidate ligand as the X-ligand or by preparing a new pyrrolidinophosphole ligand as the L-ligand. All the complexes have been evaluated in vitro for their antimalarial activity. These gold–phosphole complexes showed moderate activities with IC50 values ranging from 9.7 to 24 μM against Plasmodium falciparum chloroquine-resistant strains

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