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PIII‐14
Author(s) -
Han B.,
Yu X.,
Li G.,
Fu F.,
Zhang L.,
Zhu M.,
Yu C.
Publication year - 2006
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2005.12.222
Subject(s) - platelet , platelet aggregation , coagulation , hemorheology , medicine , pharmacology , blood viscosity
BACKGROUND/AIMS Safflor Yellow (SY), the main pigments of Carthamus tinctorius L that has been used extensively in Traditional Chinese Medicine for treatment of cardiovascular disease, was demonstrated to be an antagonist to platelet activating factor receptor and has inhibition on the platelets aggregation in animals. This study was designed to elucidate the effects of SY on the platelet aggregation and hemorrheology in healthy volunteers. METHODS SY was orally administered at dose of 3mg/kg to ten healthy male volunteers aged 25–30 years. Venous blood samples were taken before and 60, 120, 180, 240 min after administration. The hemorrheological parameters, platelet aggregation and blood coagulation time were determined. RESULTS SY could obviously attenuate the high‐sheering, middle‐sheering and low‐sheering viscosity at 180, 240 min interval (P < 0.01 or P < 0.05), compared with that of SY not given. SY strongly inhibited ADP‐induced platelet aggregation and prolonged the coagulation time at 240 min interval (P < 0.01). CONCLUSIONS SY could ameliorate the hemorheology and had a potent inhibitory effect on ADP‐induced platelet aggregation, thus it would be beneficial to the patients with cardiovascular and cerebrovascular disease, accompanied with hyperviscosity. Clinical Pharmacology & Therapeutics (2005) 79 , P62–P62; doi: 10.1016/j.clpt.2005.12.222