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PI‐3
Author(s) -
Fu F.,
Hou Y.,
Wang R.
Publication year - 2006
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2005.12.024
Subject(s) - medicine , saline , motility , anesthesia , edema , surgery , genetics , biology
BACKGROUND There is no ideal drugs for promoting the postoperative gastrointestinal motility because of their side reaction. Previously we observed the effects of escin on gastrointestinal transmit when it was given intravenously in abdominal postoperative patients. In this study the efficacy of escin on the non‐abdominal operation patients was investigated. METHODS The clinical trial was approved by the medical ethics committees. Informed consent was obtained from all patients. 19 non‐abdominal surgery patients were observed. Injection escin (ascinate sodium, 1994 launched in China) was prescribed to indicate the edema after operation and the effects of it on the intestinal motility were observed simultaneously. Of 19 patients, including mastectomy, thyroidectomy and leg diorthosis under general anaesthesia, 10 were injected intravenously escin in saline, others were given an equal volume of saline. Escin at the dose of 0.3 mg/kg was administered immediately after operation and completed in 2h. Auscultation was carried out every 1h to know when the bowel sound recovered. The first time for passage of gas (FTPG) by intestines were also recorded. RESULTS The time of recovery of bowel sounds was shorter in group of escin than that in saline group (10.0±2.9 vs 16.6±3.3, P< 0.01). The FTPG by intestines was much earlier when escin was administered (16.8±6.0 vs 26.4±5.3, P < 0.01). CONCLUSION Escin is an effective drug for promoting the gastrointestinal motility in the non‐abdominal postoperative patients. Clinical Pharmacology & Therapeutics (2005) 79 , P7–P7; doi: 10.1016/j.clpt.2005.12.024