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Effect of cobalt sulfate on histopathological features of liver in rat
Author(s) -
Mozaffarian F.,
Zakerifar A.,
Alaii J.,
Saadat H.,
Passaebakhsh P.
Publication year - 2005
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2004.12.254
Subject(s) - cobalt , cytoplasm , chemistry , pathology , medicine , physiology , biochemistry , organic chemistry
Background Regarding different cobalt pollutant compounds in manufactures like alloy industries of Air, Space and its uses in daily life and clinical uses in dentistry and orthopedic cases as prosthesis or grafts. We decided to examine cobalt toxicity. Methods Rats of Institute Pasteur were selected and after their adaptation with animal house were divided into 5 groups, 4 test groups and 1 control. In the test 4 groups 1, 3, 5, 8 & 11.5 mg Colbalt sulfate per kg body weight are injected 3 times a week for 9 weeks. The controls received 2 ml (like test volume) distilled water injectionally (ip). After 9 weeks the animals anesthesized and were dissected free and washed. After necessary histological preparation the sections were stained and studied with light microscopy. Results In group 1 (low dose) the changed tissue architecture, weak congestion, pale cytoplasm was observed. In group 2 (medium dose) the changed histoarchitecture, congestion, feathery form cytoplasm, lymphocyte infiltration, pale cytoplasm and color differences and changed lobular form were distinguished. In group 3 besides changed architecture (dispersed or nondispersed), intensive congestion, observable sinusoidal dilation, changed lobular form, focal or irregular pale cytoplasm were observed. In group 4 besides these changes fibrous bands were observed that indicates initiating fibrosis process. Conclusion Cobalt sulfate seems to have a pathological effect on the liver but the precise structural changes needs to be studied more. Clinical Pharmacology & Therapeutics (2005) 77 , P94–P94; doi: 10.1016/j.clpt.2004.12.254