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Local periodontal cytokine (tumor necrosis factor) induction by lipopolysaccharide in the mice air pouch and its relationship to the febrile response
Author(s) -
Branco L. G.,
Navarro V. P.
Publication year - 2005
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2004.12.092
Subject(s) - lipopolysaccharide , tumor necrosis factor alpha , cytokine , stimulation , medicine , pouch , immunology , pharmacology , surgery
In general, peripheral induction of cytokines plays a key role in the development of fever. The possible induction of cytokines, such as tumor necrosis factor (TNF), in periodontal tissues has never been assessed. Thus, the present study tested the hypothesis that LPS injected in protection periodontal tissue causes fever and this response involves TNF induction. The participation of TNF was assessed by a gingival intra‐pouch injection of saline or Escherichia coli lipopolysaccharide (LPS), 10 and 100μg/kg in a final volume of 30μl, in wild‐type (WT) and TNF knockout mice (KO). Body temperature (Tb) was measured before and after LPS injection. LPS injection elicited a similar increase in Tb in both WT and TNF KO mice. Thus, these results indicate that TNF may not be involved in the febrile response induced by the injection of LPS into the periodontal air pouch. If there were an activation of periodontal nerves to induce fever by a local formation of cytokines within the air pouch, TNF would not represent a likely candidate to be responsible for such a neural stimulation. Clinical Pharmacology & Therapeutics (2005) 77 , P52–P52; doi: 10.1016/j.clpt.2004.12.092