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Effect of age on the activity of cytochrome P450 2D6 using dextromethorphan phenotyping in humans
Author(s) -
Park J.,
Kim K.,
Park P.,
Lee D.,
Kim H.,
Park C.,
Shin J.
Publication year - 2005
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2004.11.094
Subject(s) - dextromethorphan , cyp2d6 , medicine , young adult , dextrorphan , pediatrics , age groups , physiology , anesthesia , demography , cytochrome p450 , metabolism , sociology
Purpose To investigate the effect of age on the activity of cytochrome P450 2D6 (CYP2D6) in humans. Methods Participants were classified and grouped as follows: neonates (less than 1 month old), infants (1–12 month old), children (3–10 year old), adolescents (10–15 year old), young adults (20–25 year old), and old adults (over 60 year old). CYP2D6 activity was assessed by measuring the formation of dextrorphan (DX) from dextromethorphan (DM) from blood samples drawn at 3hour after DM medication. Results Median metabolic ratio (MR, log[DM/DX]) of neonates, infants, children, adolescents, young adults, and old adults was −1.67, −2.37, −2.37, −2.45, −2.44, and −2.47, respectively. Probit plot data showed that there was similar distribution in CYP2D6 activity among infants, children, adolescent, young adults, and old adults but that of neonates was higher compared to other aged groups. Conclusions These results suggest that chronologically increased CYP2D6 activity in neonates may be decreased in infant age and then CYP2D6 activity may not be varied significantly throughout life. Clinical Pharmacology & Therapeutics (2005) 77 , P24–P24; doi: 10.1016/j.clpt.2004.11.094