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CYP2C9 and clinical response to antidepressant drugs in Mexican‐Americans
Author(s) -
Llerena A.,
Dorado P.,
Caéceres M.C.,
Wong M.L.,
Licinio J.
Publication year - 2005
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2004.11.092
Subject(s) - desipramine , fluoxetine , placebo , cyp2c9 , antidepressant , clinical pharmacology , medicine , pharmacology , clinical trial , psychology , serotonin , metabolism , receptor , alternative medicine , pathology , cytochrome p450 , hippocampus
Background/Aims We have found the implication of CYP2C9 in the metabolism of fluoxetine in patients. The aim of the present study was to analyze the role of CYP2C9 in the clinical response to antidepressant drugs in Mexican‐American Depressive Patients (MADP). Methods CYP2C9 genotypes were studied in 220 MADP (at least three out of four grandparents born in Mexico) treated in an eight‐week double‐blind study either with fluoxetine or desipramine. They were divided in Completers (n=138) those whom terminated the study and Dropouts (n=47), those that could not finalize the study due to side effects or other medical condition. A group of 25 did not initiate the study and 10 were Placebo responders. Results The percentage of CYP2C9*3 was higher in Dropouts compared to Completers (6.4 vs. 2.9%; OR=2.28). In the group treated with fluoxetine this percentage was much higher among Dropouts compared to Completers (11.7 vs. 3.4%; OR=3.76). However, in the group treated with desipramine the percentages were very similar (3.3% vs. 2.3%). Interestingly all Placebo responders were CYP2C9*1/*1 (wild type). Conclusions The present preliminary results seem to support a role for CYP2C9*3 in the clinical outcome of MADP treated with fluoxetine, whereas during desipramine treatment seems to be less relevant. Clinical Pharmacology & Therapeutics (2005) 77 , P24–P24; doi: 10.1016/j.clpt.2004.11.092