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Treatment of Urinary Incontinence with Anticholinergics in Patients taking Cholinesterase Inhibitors for Dementia
Author(s) -
Siegler Eugenia L.,
Reidenberg Marcus,
Reidenberg Marcus
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2004.01.015
Subject(s) - anticholinergic , clinical pharmacology , donepezil , urinary incontinence , dementia , medicine , cholinesterase , anticholinergic agents , intensive care medicine , deprescribing , pharmacology , psychology , polypharmacy , urology , disease
Clinicians often encounter patients with dementia and urge incontinence who might benefit from both an anticholinergic medication and a cholinesterase inhibitor. At first glance, this combination would seem to violate basic principles of geriatric pharmacology, as the drugs appear to be working at cross‐purposes and anticholinergic medications are notorious for worsening cognitive function in susceptible patients. A case is presented and discussed in which this combination was clinically effective and pharmacologically sound. Clinical Pharmacology & Therapeutics (2004) 75 , 484–488; doi: 10.1016/j.clpt.2004.01.015