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Comparative American and Japanese tobacco smoke uptake parameters after overnight tobacco deprivation
Author(s) -
Domino E. F.,
Kadoya C.,
Matsuoka S.,
Ni L.,
Fedewa K.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.272
Subject(s) - cotinine , nicotine , tobacco smoke , medicine , cigarette smoke , tobacco leaf , physiology , cyp2a6 , smoke , toxicology , biology , chemistry , environmental health , agricultural engineering , organic chemistry , cytochrome p450 , metabolism , engineering , cyp1a2
Tyndale et al. (2002) reported that Japanese, among various ethnic groups, have a relatively high incidence of lower activity CYP2A6 genotypes and are associated with decreased risk for tobacco smoking. Furthermore, a very large percentage of male Japanese smoke. American and Japanese overnight deprived tobacco smokers were phenotyped with respect to expired CO, plasma nicotine and cotinine, and red cell COHb. The participants were 51 American and 55 Japanese cigarette smokers of mixed gender who met similar strict criteria. American and Japanese female smokers had similar tobacco uptake parameters. American and Japanese male smokers differed; the latter had higher plasma nicotine and lower cotinine levels as well as calculated 24 hr dose of nicotine and lower exhaled CO. Japanese females and males were similar in all tobacco smoke uptake parameters. When the two racial groups were compared, irrespective of gender, the only statistically significant differences were lower mean exhaled CO levels and percent COHb in the Japanese. It is concluded that Japanese males inhale cigarettes in moderation compared to Americans. Clinical Pharmacology & Therapeutics (2004) 75 , P72–P72; doi: 10.1016/j.clpt.2003.11.272