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Genetic polymorphism of CYP2C9 in a Vietnamese population
Author(s) -
Kim K.,
Sunwoo Y.,
Ryu J.,
Lee S.,
Yoon Y.,
Cha I.,
Shin J.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.257
Subject(s) - vietnamese , allele , genetics , genotype , cyp2c9 , polymorphism (computer science) , allele frequency , population , biology , context (archaeology) , medicine , gene , environmental health , paleontology , philosophy , linguistics
CYP2C9 is the major cytochrome P450 2C enzyme in human liver and contributes to the metabolism of a number of drugs. This enzyme shows genetic polymorphism with high inter‐ethnic variations, but no report has been addressed to the genetic polymorphism in Vietnamese population. Among 12 known allelic variations, CYP2C9*2 (Arg144Cys) and CYP2C9*3(Ile359Leu) genotypes have been most characterized due to its clinical relevance to cause enzymatic defects. Genetic polymorphism of these two alleles was determined in 157 Vietnamese subjects by PCR‐RFLP method and compared with those of other ethnics. CYP2C9*2 allele was not detected in Vietnamese, which was consistent with the previous results suggesting no occurrence of CYP2C9*2 allele in East Asians including Korean, Japanese, and Chinese. This frequency is highly different from those of Caucasians (10–13%) and American (8%). Out of 157 Vietnamese subjects, 7 subjects were heterozygous for CYP2C9*3 allele, which gave allelic frequency of 2.23%. In the context of the allelic frequency of CYP2C9*3, Vietnamese is not different from African‐American (0.5%) and East Asians including Korean (1.1%), Japanese (2.1%) and Chinese (1.7–2.6%), but significantly different from American (6%) and Caucasians (8–10%) (Chi‐square test, p<0.05). Our results indicate that genetic polymorphism of CYP2C9 in Vietnamese population is similar to those of East Asians, but significantly different from those of American and Caucasians. Clinical Pharmacology & Therapeutics (2004) 75 , P68–P68; doi: 10.1016/j.clpt.2003.11.257