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The association between the CYP3A5 genotype and blood pressure
Author(s) -
Ho H.,
Pinto A.,
Hall S. D.,
Flockhart D. A.,
Li L.,
Skaar T.,
Wagner U.,
Fineberg N. S.,
Weinberger M. H.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.233
Subject(s) - blood pressure , genotype , medicine , cyp3a5 , allele , creatinine , excretion , endocrinology , urine , gastroenterology , biology , genetics , gene
A previous report indicated that the CYP3A5 *1 allele was associated with elevated blood pressure in young African Americans. We determined the frequency of the CYP3A5 *3 allele in 271 subjects (73.4% Caucasian, 34.3% hypertensives, 51.3% men) using the real time polymerase chain reaction. These subjects were part of a longitudinal study of salt sensitivity (initial mean age was 34 years). Demographics and blood pressure (BP), creatinine clearance, urine microalbumin excretion, vascular reactivity measurements and insulin sensitivity indices were recorded during the mean follow‐up of 26 years. Using Wilcoxon paired tests, we found that among Caucasians, initial BMI was higher for *1/*3 (27.2±6.0) when compared with *3/*3 (25.1±5.1) (p=0.04) and Homeostasis Model Assessment taken during follow‐up was also higher for *1/*3 (9.6±14.1) when compared with *3/*3 (5.7±8.4) (p=0.05). For African Americans, baseline systolic BP taken during the initial study was significantly higher in those with the *3/*3 genotype (146±35 mm Hg) than those with the *1/*1 (125±17.4 mm Hg, p=0.009) and the *1/*3 (119±14.1 mm Hg, p=0.0006) genotypes. Other variables tested showed no significant association with the CYP3A5 genotype. We conclude that the CYP3A5 gene may be associated with effects on BP and insulin sensitivity in a race selective manner. Clinical Pharmacology & Therapeutics (2004) 75 , P61–P61; doi: 10.1016/j.clpt.2003.11.233