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Beta 1 ‐adrenergic receptor polymorphisms and hypertension
Author(s) -
Beitelshees A. L.,
Cavallari L. H.,
Gaston K. L.,
Okorochukwu T. U.,
Johnson J. A.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.232
Subject(s) - haplotype , genotype , allele , medicine , endocrinology , biology , genetics , pharmacogenetics , gene
Purpose We sought to elucidate the association between β 1 ‐adrenergic receptor (β1AR) gene polymorphisms and hypertension (HTN). Methods We obtained BP and genetic samples from hypertensive (HT, defined as treated, or untreated with DBP>90 mmHg) Caucasians (C) and African Americans (AA) with a family history of HTN (defined as first degree relative diagnosed before age 65) and normotensive (NT) C and AA with no family history of HTN. β1AR codon 49 (Ser/Gly) and 389 (Arg/Gly) genotypes were determined by PCR and Pyrosequencing with haplotypes assigned. Allele, haplotype and diplotype frequencies were compared between NT and HT. BP was compared among NT subjects by genotype, haplotype and diplotype. Results A total of 462 patients were enrolled. Genotypes were in Hardy‐Weinberg equilibrium. Allele, haplotype, and diplotype frequencies were similar between HT and NT (see Table 1 Table 2), with separate analysis by race. We found no significant association between BP and haplotype, diplotype, or genotype in any of the NT groups. Conclusions Our data suggest that β1AR genotype and haplotype are not associated with HTN or BP among NT. Clinical Pharmacology & Therapeutics (2004) 75 , P61–P61; doi: 10.1016/j.clpt.2003.11.232Allele NT‐C HT‐C NT‐AA HT‐AAGly49 0.11 0.09 † 0.19 0.18 Gly389 0.25 * 0.23 ** 0.42 0.49* p<0.01 vs NT‐AA, ** p<0.001 vs HT‐AA, † p=0.098 vs HT‐AA.Haplotype NT‐C HT‐C NT‐AA HT‐AASer49/Arg389 0.64 0.67 0.39 0.34 Ser49/Gly389 0.25 0.24 0.42 0.48 Gly49/Arg389 0.11 0.09 0.19 0.18